Genética da suscetibilidade
Genes que fazem uma pessoa exposta ao M. leprae adoecer: de estudos de ligação e genes candidatos (PARK2/PACRG, LTA, TLR1, NOD2, LRRK2) à genética familiar e ao sequenciamento.
Lab Mira
Publicações
Linhas de pesquisa
Formas clínicas e reações
Por que pacientes evoluem para formas e reações diferentes: variantes ligadas ao espectro clínico, à reação tipo 2 (IL6) e a respostas inflamatórias excessivas (TNFSF8).
Populações isoladas da Amazônia
Epidemiologia genética em comunidades hiperendêmicas e isoladas, como a Vila do Prata (PA), onde um gene principal controla a suscetibilidade.
Resistência a fármacos
Emergência e transmissão de M. leprae resistente e multirresistente, e marcadores moleculares de resistência em grandes coortes.
Imunodiagnóstico
Novos reagentes para o diagnóstico sorológico, com phage display, mimotopos e peptídeos sintéticos.
Inteligência artificial
Apoio à decisão a partir de dados clínicos, laboratoriais e genéticos: as duas plataformas deste site.
Publicações
- 2025Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil
Ferrreira CdO, Leturiondo AL, Dos Santos CG, da Silva JB, Souza MFdA, Rego CBO, et al.
Antimicrobial Agents and Chemotherapy
- 2025Family-based genetics identifies association of CUBN, IL1RL1 and PRKN variants with leprosy in Bangladesh
Dos Santos AM, Tió-Coma M, Garcia-Codina G, Verhard EM, Uaska Sartori PV, Roy JC, et al.
Scientific Reports
- 2025Insights into leprosy epidemiology from an isolated population located in the Brazilian Amazon
de Oliveira Mackert CC, Lázaro FP, Olandowski M, D'Espindula HRS, Dos Santos AM, Sartori PVU, et al.
Scientific Reports
- 2023Allele-dependent interaction of LRRK2 and NOD2 in leprosy
Dallmann-Sauer M, Xu YZ, da Costa ALF, Tao S, Gomes TA, Prata RBDS, et al.
PLoS Pathogens
- 2023Prediction of the occurrence of leprosy reactions based on Bayesian networks
de Andrade Rodrigues RS, Heise EFJ, Hartmann LF, Rocha GE, Olandoski M, de Araújo Stefani MM, et al.
Frontiers in MedicineSEPAREH
- 2021Association of MICA and HLA-B alleles with leprosy in two endemic populations in Brazil
Jarduli LR, Alves HV, de Souza VH, Uaska Sartori PV, Fava VM, de Souza FC, et al.
International Journal of Immunogenetics
- 2020Emergence and Transmission of Drug-/Multidrug-resistant Mycobacterium leprae in a Former Leprosy Colony in the Brazilian Amazon
Rosa PS, D'Espindula HRS, Melo ACL, Fontes ANB, Finardi AJ, Belone AFF, et al.
Clinical Infectious Diseases
- 2018Genetic Susceptibility to Leprosy-From Classic Immune-Related Candidate Genes to Hypothesis-Free, Whole Genome Approaches
Cambri G, Mira MT
Frontiers in Immunology
- 2016Association Analysis Suggests SOD2 as a Newly Identified Candidate Gene Associated With Leprosy Susceptibility
Ramos GB, Salomão H, Francio AS, Fava VM, Werneck RI, Mira MT
The Journal of Infectious Diseases
- 2016Genetics of leprosy: Expected-and unexpected-developments and perspectives
Sauer ME, Salomão H, Ramos GB, D'Espindula HR, Rodrigues RS, Macedo WC, et al.
Clinics in Dermatology
- 2015Association of TNFSF8 regulatory variants with excessive inflammatory responses but not leprosy per se
Fava VM, Cobat A, Van Thuc N, Latini AC, Stefani MM, Belone AF, et al.
The Journal of Infectious Diseases
- 2014Influence of KIR genes and their HLA ligands in the pathogenesis of leprosy in a hyperendemic population of Rondonópolis, Southern Brazil
Jarduli LR, Alves HV, de Souza-Santana FC, Marcos EV, Pereira AC, Dias-Baptista IM, et al.
BMC Infectious Diseases
- 2014NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians
Sales-Marques C, Salomão H, Fava VM, Alvarado-Arnez LE, Amaral EP, Cardoso CC, et al.
Human Genetics
- 2014Phage display and synthetic peptides as promising biotechnological tools for the serological diagnosis of leprosy
Alban SM, de Moura JF, Thomaz-Soccol V, Bührer Sékula S, Alvarenga LM, Mira MT, et al.
PLoS One
- 2013Identification of mimotopes of Mycobacterium leprae as potential diagnostic reagents
Alban SM, de Moura JF, Minozzo JC, Mira MT, Soccol VT
BMC Infectious Diseases
- 2013Susceptibility to leprosy is associated with M-ficolin polymorphisms
Boldt AB, Sanchez MI, Stahlke ER, Steffensen R, Thiel S, Jensenius JC, et al.
Journal of Clinical Immunology
- 2013Toll-like receptor 1 N248S single-nucleotide polymorphism is associated with leprosy risk and regulates immune activation during mycobacterial infection
Marques Cde S, Brito-de-Souza VN, Guerreiro LT, Martins JH, Amaral EP, Cardoso CC, et al.
The Journal of Infectious Diseases
- 2012Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction
Sousa AL, Fava VM, Sampaio LH, Martelli CM, Costa MB, Mira MT, et al.
The Journal of Infectious Diseases
- 2012Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase
Gomes HJ, Souza RL, Prevedello FC, Mira MT, Chautard-Freire-Maia EA
Journal of Tropical Medicine
- 2011Genetic risk factors for human susceptibility to infections of relevance in dermatology
Sardinha JF, Tarlé RG, Fava VM, Francio AS, Ramos GB, Ferreira LC, et al.
Anais Brasileiros de Dermatologia
- 2011Leprosy and HIV coinfection: a critical approach
Massone C, Talhari C, Ribeiro-Rodrigues R, Sindeaux RH, Mira MT, Talhari S, et al.
Expert Review of Anti-infective Therapy
- 2011TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: a genetic epidemiology assessment, meta-analysis, and functional study
Cardoso CC, Pereira AC, Brito-de-Souza VN, Duraes SM, Ribeiro-Alves M, Nery JA, et al.
The Journal of Infectious Diseases
- 2010A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil
Lázaro FP, Werneck RI, Mackert CC, Cobat A, Prevedello FC, Pimentel RP, et al.
The Journal of Infectious Diseases
- 2010Leprosy and HIV coinfection: a clinical, pathological, immunological, and therapeutic study of a cohort from a Brazilian referral center for infectious diseases
Talhari C, Mira MT, Massone C, Braga A, Chrusciak-Talhari A, Santos M, et al.
The Journal of Infectious Diseases
- 2009PCR-restriction fragment length polymorphism analysis as a tool for Mycobacterium species identification in lepromas for lepromin production
Alban SM, Sella SR, Miranda RN, Mira MT, Soccol VT
Leprosy Review
- 2007Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy
Alcaïs A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M, et al.
Nature Genetics
- 2006
- 2004Susceptibility to leprosy is associated with PARK2 and PACRG
Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, et al.
Nature
- 2003Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population
Mira MT, Alcaïs A, Van Thuc N, Thai VH, Huong NT, Ba NN, et al.
Nature Genetics
- 2003Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes
Mira MT, Alcais A, di Pietrantonio T, Thuc NV, Phuong MC, Abel L, et al.
Genes and Immunity